Published: Thu, November 22, 2018
Health Care | By Belinda Paul

Allergic to peanuts? New hope develops after promising clinical trial

Allergic to peanuts? New hope develops after promising clinical trial

"The doses patients tolerate are high enough to likely prevent reactions with cross contamination or allow patients to eat foods with "may contain" or "manufactured in"-type labels", added Ponda, who is assistant chief in the Division of Allergy and Immunology at Northwell Health, in Great Neck, N.Y. She was not involved with the study".

The AR101 group received increasing amounts of peanut protein until they reached the "maintenance dose" of 300mg, equivalent to one peanut a day, on which they then remained for approximately 24 weeks. The publication notes that, "despite vigilance, accidental exposures may occur and cause reactions of unpredictable severity, even with small amounts of allergen, leading to a lifelong risk of severe reactions".

There's hope for a solution for people with peanut allergies.

"We're excited about the potential to help children and adolescents with peanut allergy protect themselves against accidentally eating a food with peanut in it", said allergist Dr Stephen Tilles, ACAAI past president, study co-author, and consulting advisor for Aimmune Therapeutics.

Ms Pratt said by the end of the year-long trial Emily was able to tolerate around seven peanuts.

One-third of the participants were assigned to the control (placebo) group, and the remainder were given daily doses of protein powder. "Before Emily took part we were uncomfortable being more than twenty minutes away from a hospital and she wasn't able to attend play dates or parties without me or my husband being there". Again, this isn't meant as a be-all-end-all solution to peanut allergies; it's simply meant to protect patients against life-threatening reactions (anaphylactic shock) when they unknowingly come into contact with a small dose of peanut.

'The impact on our family life was huge'.

The results, published in the New England Journal of Medicine, showed 67% of the children and teenagers given peanut protein could tolerate at least 600mg, compared with just 4% on the dummy placebo.

For parents of kids with peanut allergies, a new study holds "lifesaving" hope.

'Until recently there has been nothing to offer peanut allergy sufferers other than education around peanut avoidance and recognition and self-treatment of allergic reactions'.

In the United States from 1997 to 2008, peanut allergy tripled (from 1-in-250 children to 1-in-70 children), Aimmune Therapeutics reported.

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